HiPP COMBIOTIC® video
Combining the best science and nature: For our goal of our research on breast milk and gut microbiota for 20 years. Learn more about our pre- & probiotics in our infant formulae!
Definitely the ideal combination
Based on the latest findings of breast milk research, the Nutritional Science department of HiPP has developed a new generation of infant milk: HiPP COMBIOTIC®.
NEW: HiPP ORGANIC COMBIOTIC® with Metafolin®
- natural folate form (5-MTHF) as found in human milk1
- immediately available to the body, it does not need to be metabolised
- Metafolin® is safe for use in formulae2
Natural probiotic
- Lactobacillus fermentum hereditum® CECT5716
- unchanged original lactic acid culture from breast milk1, 2, 3
- a primary coloniser of the intestine4
- supports a healthy intestinal flora5
- contributes to modulation of immune response6, 7
Proven prebiotic: GOS
- galacto-oligosaccharides obtained from organic lactose
- stool consistency and frequency similar to breastfed children8–11, 5
- promotes the growth of beneficial intestinal bacteria8-10, 5
- proven to be safe12
Clinical studies prove: Safety & significantly fewer infections
HiPP ORGANIC COMBIOTIC® supports the development of a healthy intestinal microbiota with its synbiotic composition1,2:
Clinical studies1, 2 prove:
- combination of pro- and prebiotics is safe and beneficial
- significantly fewer infections
- combination of GOS + L. fermentum significantly better than prebiotic (GOS) alone
References
1 Maldonado J et al. J Pediatr Gastroenterol Nutr 2012; 54(1):55–61
2 Gil-Campos M et al. Pharmacol Res 2012; 65(2):231–238
3 Maldonado-Lobon JA et al. Pharmacol Res 2015; 95–96:12–19
1 Maldonado J et al. J Pediatr Gastroenterol Nutr 2012; 54(1):55–61
2 Gil-Campos M et al. Pharmacol Res 2012; 65(2):231–238
3 Maldonado-Lobon JA et al. Pharmacol Res 2015; 95–96:12–19
Important palmitic acid
- saturated fatty acids predominate in breast milk
- important for good tolerability of formula13
> less watery and more yellowy stools (similar to those of breastfed children)
Omega 3 and 6 LCP
- evidence-based and recommended14
- important for cognitive and visual development
- optimum ratio of omega 3 and 6 LCP (DHA and ARA)
Appropriately low protein content
- < 2.0 g/100 kcal, tailored to physiological needs15
- obtained from high-quality organic milk and whey
Important notice: Depending on country-specific markets, the HiPP product range can differ. Please visit for detail your local consumer-website.
HiPP ORGANIC COMBIOTIC® supplies all the key, high-quality macro- and micronutrients in the appropriate quantities.
Suitable HiPP info material
HiPP Scientific Dossier L.ferm. GOS (AL47836)
L. fermentum CECT5716 and Galacto-oligosaccharides in HiPP ORGANIC COMBIOTIC® formulae.
References:
1 1 Page R et al. Am J Clin Nutr. 2017 May; 105(5): 1101–1109
2 Troesch B et al. PLoS ONE 2019; 14(8): e0216790 LB et al. J Nutr. 2015 ;145:1636–1680
3 Martin R et al. J Pediatr 2003; 143(6):754–758
4 Martin R et al. J Hum Lact 2005; 21(1):8–17
5 Blaut M & Loh C in: Bischoff SC: Probiotika, Präbiotika und Synbiotika; Thieme 2009; 2–23
6 Maldonado-Lobon JA et al. Pharmacol Res 2015; 95–96:12–19
7 EFSA: The EFSA-Journal 2007; 587:1–16
8 FDA. 2015; GRAS Notices GRN No. 531
9 Ben XM et al. World J Gastroenterol 2008; 14(42):6564–6568
10 Fanaro S et al. J Pediatr Gastroenterol Nutr. 2009; 48:82–88
11 Sierra C et al. Eur J Nutr 2015; 54(1):89–99
12 Ashley C et al. Nutrition Journal 2012; 11:38
13 Kunz C et al. Annu Rev Nutr. 2000; 20:699–722
14 Gibson CR, Roberfroid MB. J Nutr 1995; 125(6):1401–1412
15 FDA. 2008; GRAS Notices GRN No.236
16 Koletzko B et al. Am J Clin Nutr 2009, 89(6):1836–1845
17 Koletzko B et al. AJCN 2020; 111: 10–16
18 Koletzko B et al. Am J Clin Nutr 2009, 89(6):1836–1845
HiPP for Health Care Professionals