Low protein content and improved protein quality

Less is more: HiPP 1 COMBIOTIC® has a low protein content, but a high protein quality

Breast milk is also considered to be the Gold Standard for protein intake! The appropriately reduced protein intake of infants could provide an effective contribution to preventing obesity in children (1). This is why the experts recommend the promotion of breastfeeding and reduction of the protein content in infant formula.
HiPP has put these current recommendations into practice and is now offering HiPP COMBIOTIC® first infant milk with reduced protein content in many countries. Safety, tolerance and the good satiety effect of the new milk have been demonstrated in a clinical study.

Early-protein hypothesis – an explanation

The early-protein hypothesis suggests that high protein intake of infants leads to increased plasma and tissue concentrations of insulin-releasing amino acids through metabolic programming, which in turn stimulates insulin and IGF1 (insulin-like-growth factor 1) (2) .

Confirmation of the hypothesis through the results of the EU Childhood Obesity Study

The early-protein hypothesis was confirmed by the CHOPs study (EU Childhood Obesity Project) that showed faster weight gain and higher adipogenous activity in the first two years and ultimately a higher long-term risk of adipositas (3).
More on the CHOP-Study

HiPP COMBIOTIC® first infant milk – has a low protein content, but a high protein quality

The reduced protein intake of infants – through promotion of breastfeeding and/or reducing the protein content of infant milk – could provide an effective contribution to preventing obesity in children (1).
Leading nutrition experts therefore recommend a protein content of around 1.8 g per 100 kcal for infant formulae (3).

HiPP COMBIOTIC® first infant milk with reduced protein content meets the recommendations made by nutritional experts. Its protein content is 1.89 g per 100 kcal. This low value has been made possible through the use of the whey protein alpha-lactalbumin which is of especially high nutritional value.

  • Protein amount is in line with the latest experts’ recommendations (3)
  • Optimised protein quality (with alpha-lactalbumin, a high-quality whey protein)
  • Clinical trial has shown safety and suitability of HiPP COMBIOTIC® first infant milk (4)
    - Growth appropriate to age – also confirmed from 4 years of age 20
    - Protein intake is closer to the protein intake of breastfed children
    - Positive influence on infant’s satiety
    - Improved energetic efficiency

# Intervention period: birth to 4 months; intervention group with protein-reduced infant formula (protein 1.89 g/100 kcal), n=82; control group with standard infant formula (protein 2.2 g/100 kcal), n=82; reference group with breastfed infants, n=92. The children were examined and anthropometrically measured after 30, 60, 90 and 120 days of life.

The protein intake through breast milk was calculated according to the drinking amounts of both the intervention and the control group during the respective examination appointments; protein content of breast milk 1.2 g/100 ml corresponding to 1.7 g/100 kcal (5). Differences between protein-reduced and control formula are significant: ** P< 0.01; *** P< 0.001.

(4) Fleddermann M et al. Clin Nutr 2014; 33(4): 588-595
(5) Nommsen LA et al. Am J Clin Nutr 1991; 53: 457-465

HiPP 1 Combiotic® - clinical studies prove safety and age-appropriate growth

    In this prospective randomised double-blind trial over four months BeMIM (Belgrade Munich Infant Milk Trial, (4)) 213 healthy infants were given either protein-reduced milk (with lactalbumin) or standard food. There was no difference in the development between the children of the two groups and no setback as far as satiety was concerned. In fact, quite the reverse was the case and there were even indications suggesting a better energetic efficiency of the infant milk (growth in relation to energy intake). The follow-up of the study (6) confirmed age-appropriate growth also after four years of observation.

    BeMIM-Study- Review
    Fleddermann et al.: Energetic efficiency of infant formulae: A review. Ann Nutr Metab 2014; 64:276–283

    (1) Weber M et al. Am J Clin Nutr 2014; 99: 1041-51
    (2) Arenz S et al. Int J Obesity 2004; 28: 1247-56
    (3) Koletzko B et al. Am J Clin Nutr 2009; 89 (Suppl): 1S-7S
    (4) Fleddermann M et al. Clin Nutr 2014; 33: 588-95
    (5) Nommsen LA et al. Am J Clin Nutr 1991; 53(2):457-465
    (6) Fleddermann M et al. Abstracts booklet 49th ESPGHAN Annual Meeting 2016; 62 (suppl 1): 6

    Important notice: Depending on country-specific legislation and recommendation, the ingredients in HiPP COMBIOTIC formula can differ. Please visit for detail your local consumer-website.

    Suitable HiPP info material

    HiPP COMBIOTIC® (AL47803)

    Professional Information: The new generation of milk formula: Important building blocks provide for a good start.

    HiPP Scientific Dossier L.ferm. GOS (AL47836)

    L. fermentum CECT5716 and Galacto-oligosaccharides in HiPP ORGANIC COMBIOTIC® formulae.