Summarised by Sandra Rühle, M.Sc. in nutritional science
Limosilactobacillus fermentum CECT5716 is a probiotic strain that occurs naturally in human milk. In addition to its safety, it is believed to have functional, anti-infectious, immunomodulatory, and anti-inflammatory properties, making it an ideal ingredient in formula. This prompted the team around Pastor-Villaescusa to conduct a systematic literature review and meta-analysis on the effect of the strain.
For an evidence-based evaluation of this effect, they conducted a systematic literature search until mid-June 2021. They found three RCTs (randomised controlled trials) that were considered relevant. These trials looked at a total of 512 infants, 435 of whom were also included in follow-up analyses. The study populations of all RCTs consisted exclusively of formula-fed infants between one and six months of age.