The two double-blind, randomised, placebo-controlled studies GOLF 1 & GOLF 2 (GO= GOS, LF= L. fermentum) investigated the safety and effects of infant formula with pre- and probiotics. Children with a pre- and probiotic (synbiotic) infant formula were compared with children from the control group that received formula with only prebiotics (GOS)1.
Result: The combined administration of natural lactic acid culture L. fermentum hereditum® and GOS (Galacto-Oligosaccharide) in infant (GOLF 2 Study) as well as in follow-on formula (GOLF 1) proved safe and well-tolerated.
Additionally, in both studies, the administration of a pre- und probiotic formula clearly lowered the incidence of gastrointestinal infections: Over a six-month period, there were 71% 2 fewer cases of diarrhea with the infant formula and 46% 1 fewer with the follow-on formula than in the comparison group.
Fig. 1: Study with Infant formula (GOLF 2)2: Incidence of infection in relation to infant formula administered